Anti-Human SLC7A11 Polyclonal Antibody (HC159014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HC159014

品牌

abinScience

描述

Anti-Human SLC7A11 Polyclonal Antibody (HC159014) is a rabbit polyclonal antibody detecting SLC7A11. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human SLC7A11 (Met1-Arg42).

靶标

Amino acid transport system xc-, Calcium channel blocker resistance protein CCBR1, Cystine/glutamate transporter, SLC7A11, Solute carrier family 7 member 11, xCT

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q9UPY5

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Cystine/glutamate transporter (SLC7A11) is a ~55 kDa protein. Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress. The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine. Acts as an inhibitor of ferroptosis by mediating the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis. Also inhibits ferroptosis by acting as an atypical proton transporter that mediates a slow proton efflux from lysosomes via cystine and glutamate flux.

1. Bridges, CC. et al. (2001) Investigative ophthalmology & visual science 42, 47-54. PMID: 11133847

2. Bassi, MT. et al. (2001) Pflugers Archiv : European journal of physiology 442, 286-96. PMID: 11417227

3. Jiménez-Vidal, M. et al. (2004) The Journal of biological chemistry 279, 11214-21. PMID: 14722095

4. Gasol, E. et al. (2004) The Journal of biological chemistry 279, 31228-36. PMID: 15151999

5. Parker, JL. et al. (2021) Nature communications 12, 7147. PMID: 34880232

6. Fiore, A. et al. (2022) Molecular cell 82, 920-932.e7. PMID: 35245456

7. Yan, R. et al. (2022) Cell research 32, 687-690. PMID: 35352032

8. Zhang, HL. et al. (2025) Nature chemical biology 21, 1531-1543. PMID: 40246981

Note

For research use only

图片

参考文献

产品说明书

Anti-Human SLC7A11 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SLC7A11 Polyclonal Antibody (HC159014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SLC7A11 Polyclonal Antibody (HC159014)

概述

图片

参考文献

产品说明书

相关产品推荐

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