Anti-Human LTK Polyclonal Antibody (HB966014)

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规格：

50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HB966014

品牌

abinScience

描述

Anti-Human LTK Polyclonal Antibody (HB966014) is a rabbit polyclonal antibody detecting LTK. Suitable for Human.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human LTK (Ser67-Asn380).

靶标

EC:2.7.10.1, LTK, Leukocyte tyrosine kinase receptor, Protein tyrosine kinase 1, TYK1

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P29376

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Leukocyte tyrosine kinase receptor (LTK) is a ~91 kDa protein. Receptor with a tyrosine-protein kinase activity. Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival.

1. Honda, H. et al. (1999) Oncogene 18, 3821-30. PMID: 10445845

2. Farhan, H. et al. (2010) The Journal of cell biology 189, 997-1011. PMID: 20548102

3. Reshetnyak, AV. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 8340-8345. PMID: 30061385

4. De Munck, S. et al. (2021) Nature 600, 143-147. PMID: 34646012

5. Yamada, S. et al. (2008) Neuroreport 19, 1733-8. PMID: 18849880

6. Ueno, H. et al. (1997) Oncogene 14, 3067-72. PMID: 9223670

Note

For research use only

图片

Western blot

Western blot analysis was performed using anti-LTK polyclonal antibody at 1ug/mL on various samples.
Lane 1: K562 cell lysate
Lane 2: HL-60 cell lysate
Lane 3: THP-1 cell lysate

参考文献

产品说明书

Anti-Human LTK Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human LTK Polyclonal Antibody (HB966014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human LTK Polyclonal Antibody (HB966014)

概述

图片

参考文献

产品说明书

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