Anti-Human mGlyR/GPR158 Recombinant Nanobody (SAA2791) (HE024013)

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概述

货号	HE024013
品牌	abinScience
描述	Anti-Human mGlyR/GPR158 Nanobody (SAA2791) (HE024013) is a alpaca monoclonal antibody detecting GPR158. Suitable for Human.
种属反应性	Human
应用	ELISA
宿主	Alpaca
克隆类型	Monoclonal
同种型	VHH-His
克隆号	SAA2791
靶标	G-protein coupled receptor 158, GPR158, KIAA1136, Metabotropic glycine receptor, mGlyR
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q5T848
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
重悬	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Metabotropic glycine receptor (mGlyR/GPR158) is a ~135 kDa protein. Metabotropic receptor for glycine that controls synapse formation and function in the brain. Acts as an atypical G-protein coupled receptor that recruits and regulates the RGS7-GNB5 complex instead of activating G proteins. In absence of glycine ligand, promotes the GTPase activator activity of RGS7, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Glycine-binding changes the conformation of the intracellular surface, inhibiting the GTPase activator activity of the RGS7-GNB5 complex, promoting G protein alpha subunits into their active GTP-bound form and regulating cAMP levels. Also able to bind taurine, a compound closely related to glycine, but with a two-fold lower affinity. 1. Laboute, T. et al. (2023) Science (New York, N.Y.) 379, 1352-1358. PMID: 36996198 2. Hajj, M. et al. (2019) Molecular pharmacology 96, 233-246. PMID: 31189666
Note	For research use only

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参考文献

产品说明书

Anti-Human mGlyR/GPR158 Recombinant Nanobody (SAA2791).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

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抗体

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Anti-Human mGlyR/GPR158 Recombinant Nanobody (SAA2791) (HE024013)

概述

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参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human mGlyR/GPR158 Recombinant Nanobody (SAA2791) (HE024013)

概述

图片

参考文献

产品说明书

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