Caprin-1 (CAPRIN1) is a ~78 kDa protein. mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Plays an essential role in cytoplasmic stress granule formation. Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs. In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation. 1. Solomon, S. et al. (2007) Molecular and cellular biology 27, 2324-42. PMID: 172106332. Kim, TH. et al. (2019) Science (New York, N.Y.) 365, 825-829. PMID: 314397993. Pavinato, L. et al. (2023) Brain : a journal of neurology 146, 534-548. PMID: 359799257. Guillén-Boixet, J. et al. (2020) Cell 181, 346-361.e17. PMID: 323025728. Kim, TH. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 340747929. Toyama, Y. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2210492119. PMID: 36040869 | 
