Anti-Mouse PPARGC1A Polyclonal Antibody (MP446014)

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概述
图片
参考文献
产品说明书

概述

货号

MP446014

品牌

abinScience

描述

Anti-Mouse PPARGC1A Polyclonal Antibody (MP446014) is a rabbit polyclonal antibody detecting peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b; Ppargc1a. Suitable for Rat, Human, and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Mouse PPARGC1A (Pro529-Arg797).

靶标

peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b; Ppargc1a

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

O70343

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

背景

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) is a ~90 kDa protein. Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program.

1. Puigserver, P. et al. (2003) Nature 423, 550-5. PMID: 12754525

2. Rodgers, JT. et al. (2005) Nature 434, 113-8. PMID: 15744310

3. Ruas, JL. et al. (2012) Cell 151, 1319-31. PMID: 23217713

4. Puigserver, P. et al. (1998) Cell 92, 829-39. PMID: 9529258

Note

For research use only

图片

参考文献

产品说明书

Anti-Mouse PPARGC1A Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse PPARGC1A Polyclonal Antibody (MP446014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse PPARGC1A Polyclonal Antibody (MP446014)

概述

图片

参考文献

产品说明书

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