Anti-Mouse CD120a (55R-593) In Vivo Antibody - Low Endotoxin (ICH1069-100mg)

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

This is clone 55R-593, an Armenian Hamster IgG1 monoclonal antibody raised against mouse CD120a (TNF Receptor I, TNFR1/p55). Because it is generated in Armenian hamster against a mouse target, it is well suited to in-vivo and functional studies in mouse models, where a non-mouse host isotype helps limit unwanted host anti-antibody responses during repeat dosing. The antibody is supplied research-grade with low endotoxin (<1 EU/mg; ultra-low <0.5 EU/mg options), a format specifically intended for in-vivo administration and functional assays where endotoxin contamination would otherwise confound cytokine and inflammatory readouts. It is available in bulk milligram-to-gram quantities to support multi-cohort animal studies and longitudinal dosing schedules. Validated applications include immunoprecipitation and Western blot, making it useful for confirming target engagement and for biochemical characterization of TNFR1 alongside functional work. The product is for research use only (RUO) and is not intended for diagnostic or therapeutic use. All content here is guidance for ichorbio to review before publishing. CD120a, also known as TNF Receptor 1 (TNFR1, p55/p60, gene Tnfrsf1a; UniProt P25118), is one of the two principal receptors for tumor necrosis factor (TNF), the other being TNFR2/CD120b. TNFR1 is expressed broadly across most nucleated cell types and can be engaged by both soluble and membrane-bound TNF. It contains an intracellular death domain, and ligand engagement drives assembly of signaling complexes that can activate NF-kB and MAPK pathways to promote inflammation and cell survival, or, alternatively, recruit death-domain adaptors to trigger apoptosis or necroptosis. Through these outputs TNFR1 is a central mediator of inflammatory responses, host defense, tissue homeostasis, and, when dysregulated, of chronic inflammatory and autoimmune pathology. Because it drives much of TNF's pro-inflammatory and cytotoxic activity, TNFR1 is a key node studied in models of sepsis, autoimmunity, and inflammatory tissue injury.

Variety of cell types at low levels