Anti-Mouse CD183 (CXCR3-173) In Vivo Antibody - Low Endotoxin (ICH1201-50mg)

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

This is the CXCR3-173 clone, an Armenian hamster IgG monoclonal raised against mouse CD183 (CXCR3), supplied in a low-endotoxin, in-vivo-ready format for functional studies in mouse models. CXCR3-173 is a widely used clone that recognizes mouse CXCR3 and is validated here for flow cytometry and neutralization, making it well suited to work where the goal is to block chemokine-driven receptor signaling and trafficking rather than simply to identify CXCR3-expressing cells. The hamster IgG framework is a common, well-tolerated backbone for in-vivo mouse antibodies. Because the material is offered at research-grade low endotoxin (<1 EU/mg; ultra-low <0.5 EU/mg options), it is appropriate for injection into animals where endotoxin contamination would otherwise confound immune readouts. It is available in bulk milligram-to-gram quantities to support dosing across cohorts and repeat-injection schedules. The product is for research use only. All content here is guidance for ichorbio to review before publishing. CD183, better known as CXCR3, is a G-protein-coupled chemokine receptor expressed predominantly on activated T lymphocytes (especially Th1 CD4+ and effector/effector-memory CD8+ cells), NK and NKT cells, and subsets of B cells and plasmacytoid dendritic cells. It binds the interferon-inducible CXC chemokines CXCL9 (MIG), CXCL10 (IP-10) and CXCL11 (I-TAC), which are produced in inflamed tissues largely in response to IFN-gamma. Engagement drives directional migration and retention of effector lymphocytes into sites of Th1-type inflammation, infection and tumours, positioning CXCR3 as a central coordinator of effector-cell trafficking. Because of this, CXCR3 is a marker of the Th1/effector phenotype and a functional axis studied in autoimmunity, transplant rejection, antiviral immunity and antitumour T-cell infiltration. It signals through Gi-coupled pathways to reorganize the cytoskeleton and promote adhesion and chemotaxis.

CXCL3 is expressed on primary memory phenotype CD4+ and CD8+ T cells, naturally occurring CD4+CD25+ Foxp3+ regulatory T cells, natural killer (NK) T cells, and approximately 25% of NK cells. CXCR3-173 recognizes an epitope of CXCR3 expressed on the surface of activated mouse splenocytes.