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Anti-Human NT-ProBNP Monoclonal Antibody (1A345) (HB840025)

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概述
货号HB840025
品牌abinScience
描述
Anti-Human NT-ProBNP Monoclonal Antibody (1A345) [1A345] (HB840025) is a mouse monoclonal antibody detecting NT-proBNP in CLIA. Suitable for Human.
种属反应性Human
应用CLIA
宿主Mouse
同种型IgG
克隆号1A345
克隆类型Monoclonal
免疫原Human NT-ProBNP Protein.
靶标Natriuretic peptides B, Brain natriuretic factor prohormone, preproBNP, proBNP, Gamma-brain natriuretic peptide, Iso-ANP, NT-proBNP, NT-pro-BNP, NT-proBNP(1-76), proBNP(3-108), NPPB
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P16860
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Natriuretic peptides B (NT-ProBNP) is a ~14 kDa protein. Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.

1. Koller, KJ. et al. (1991) Science (New York, N.Y.) 252, 120-3. PMID: 1672777
2. Heublein, DM. et al. (2007) Hypertension (Dallas, Tex. : 1979) 49, 1114-9. PMID: 17372040
3. Yoshimura, M. et al. (1991) Circulation 84, 1581-8. PMID: 1914098
4. Jensen, KT. et al. (1998) The American journal of physiology 274, F63-72. PMID: 9458824
5. Liang, F. et al. (2007) Journal of the American College of Cardiology 49, 1071-8. PMID: 17349887
6. Ralat, LA. et al. (2011) The Journal of biological chemistry 286, 4670-9. PMID: 21098034
7. Huntley, BK. et al. (2015) Circulation. Heart failure 8, 89-97. PMID: 25339504
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Anti-Human NT-ProBNP Monoclonal Antibody (1A345)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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