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Anti-Human CD31/PECAM1 Monoclonal Antibody (1A433) (HB004035)

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概述
货号HB004035
品牌abinScience
描述
Anti-Human CD31/PECAM1 Monoclonal Antibody (1A433) [1A433] (HB004035) is a mouse monoclonal antibody detecting PECAM1 in ELISA. Suitable for Human.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
种属反应性Human
应用ELISA
宿主Mouse
同种型IgG2a
克隆号1A433
克隆类型Monoclonal
免疫原Recombinant Human CD31/PECAM1 protein.
靶标Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, GPIIA', PECA1, CD31, PECAM1
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P16284
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Platelet endothelial cell adhesion molecule (CD31/PECAM1) is a ~82 kDa protein. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal.

1. Sachs, UJ. et al. (2007) The Journal of biological chemistry 282, 23603-12. PMID: 17580308
2. Dasgupta, B. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 5041-51. PMID: 19342684
3. Hu, M. et al. (2016) Scientific reports 6, 38655. PMID: 27958302
4. Brown, S. et al. (2002) Nature 418, 200-3. PMID: 12110892
5. Yeh, JC. et al. (2008) Biochemistry 47, 9029-39. PMID: 18672896
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Anti-Human CD31/PECAM1 Monoclonal Antibody (1A433)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human CD31/PECAM1 Monoclonal Antibody (1A433)

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