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Anti-Human MRGPRX2/MRGX2 Monoclonal Antibody (1A452) (HP714025)

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概述
货号HP714025
品牌abinScience
描述
Anti-Human MRGPRX2/MRGX2 Monoclonal Antibody (1A452) [1A452] (HP714025) is a mouse monoclonal antibody in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
  • ●Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Mouse
克隆类型Monoclonal
同种型IgG1
克隆号1A452
免疫原Recombinant Human MRGPRX2/MRGX2 Protein.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q96LB1
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名Mas-related G-protein coupled receptor member X2, MRGX2, MRGPRX2
背景

Mas-related G-protein coupled receptor member X2 (MRGPRX2/MRGX2) is a ~37 kDa protein. Mast cell-specific G protein-coupled receptor for basic secretagogues, which regulates mast cell degranulation and itch-related hypersensitivity reactions. A secretagogue is an agent that promotes the secretion of hormones, neurohormones, chemical neurotransmitters or other compounds synthesized and secreted by cells. Basic secretagogues comprise a set of cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. MRGPRX2 is both coupled to G(q) and G(i) G proteins: G(q) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i) coupling mediates inhibition of adenylate cyclase activity.

1. Subramanian, H. et al. (2011) The Journal of biological chemistry 286, 44739-49. PMID: 22069323
2. McNeil, BD. et al. (2015) Nature 519, 237-41. PMID: 25517090
3. Lansu, K. et al. (2017) Nature chemical biology 13, 529-536. PMID: 28288109
4. Cao, C. et al. (2021) Nature 600, 170-175. PMID: 34789874
5. Yang, F. et al. (2021) Nature 600, 164-169. PMID: 34789875
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Anti-Human MRGPRX2/MRGX2 Monoclonal Antibody (1A452)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human MRGPRX2/MRGX2 Monoclonal Antibody (1A452)

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