Anti-GMNN Polyclonal Antibody (HF969014)

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概述
图片
参考文献
产品说明书

概述

货号

HF969014

品牌

abinScience

描述

Anti-GMNN Polyclonal Antibody (HF969014) is a rabbit polyclonal antibody detecting GMNN in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human GMNN (Met1-Ile209).

靶标

Geminin, GMNN

纯化方式

Purified by antigen affinity column.

Accession号

O75496

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Geminin (GMNN) is a ~23 kDa protein. Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.

1. Sugimoto, N. et al. (2004) The Journal of biological chemistry 279, 19691-7. PMID: 14993212

2. Miotto, B. et al. (2010) Molecular cell 37, 57-66. PMID: 20129055

3. Caillat, C. et al. (2013) The Journal of biological chemistry 288, 31624-34. PMID: 24064211

4. McGarry, TJ. et al. (1998) Cell 93, 1043-53. PMID: 9635433

Note

For research use only.

图片

参考文献

产品说明书

Anti-GMNN Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-GMNN Polyclonal Antibody (HF969014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-GMNN Polyclonal Antibody (HF969014)

概述

图片

参考文献

产品说明书

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