Anti-TPPP Polyclonal Antibody (HF892014)

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概述
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参考文献
产品说明书

概述

货号

HF892014

品牌

abinScience

描述

Anti-TPPP Polyclonal Antibody (HF892014) is a rabbit polyclonal antibody detecting TPPP in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human TPPP (Ala8-Thr210).

靶标

25 kDa brain-specific protein, TPPP/p25, Tubulin polymerization-promoting protein, p24, p25-alpha, TPPP, TPPP1

纯化方式

Purified by antigen affinity column.

Accession号

O94811

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Tubulin polymerization-promoting protein (TPPP) is a ~23 kDa protein. Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath. Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes. Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear. In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network.

1. Fu, MM. et al. (2019) Cell 179, 132-146.e14. PMID: 31522887

2. Doi, S. et al. (2021) Cell calcium 96, 102404. PMID: 33831707

3. Zotter, A. et al. (2011) FEBS letters 585, 803-8. PMID: 21316364

4. Zotter, Á. et al. (2011) Biochemistry 50, 9568-78. PMID: 21995432

5. Vincze, O. et al. (2006) Biochemistry 45, 13818-26. PMID: 17105200

6. Hlavanda, E. et al. (2007) The Journal of biological chemistry 282, 29531-9. PMID: 17693641

7. Acevedo, K. et al. (2007) Experimental cell research 313, 4091-106. PMID: 18028908

8. DeBonis, S. et al. (2015) Scientific reports 5, 13242. PMID: 26289831

9. Tokési, N. et al. (2010) The Journal of biological chemistry 285, 17896-906. PMID: 20308065

Note

For research use only.

图片

参考文献

产品说明书

Anti-TPPP Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-TPPP Polyclonal Antibody (HF892014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-TPPP Polyclonal Antibody (HF892014)

概述

图片

参考文献

产品说明书

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