Anti-ALDH1A1 Polyclonal Antibody (HF669014)

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概述
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参考文献
产品说明书

概述

货号

HF669014

品牌

abinScience

描述

Anti-ALDH1A1 Polyclonal Antibody (HF669014) is a rabbit polyclonal antibody detecting ALDH1A1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Equus caballus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human ALDH1A1 (Met1-Ser501).

靶标

Aldehyde dehydrogenase, cytosolic, Retinal dehydrogenase 1, ALDH-E1, RalDH1, Aldehyde dehydrogenase family 1 member A1, ALDH1A1, ALDH1, RALDH 1, ALDC, ALHDII, PUMB1

纯化方式

Purified by antigen affinity column.

Accession号

P00352

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Aldehyde dehydrogenase 1A1 (ALDH1A1) is a ~54 kDa protein. Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid. Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic. Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification.

1. Manzer, R. et al. (2003) DNA and cell biology 22, 329-38. PMID: 12941160

2. Choudhary, S. et al. (2005) Investigative ophthalmology & visual science 46, 259-67. PMID: 15623782

3. Collard, F. et al. (2007) Biochimie 89, 369-73. PMID: 17175089

4. Xiao, T. et al. (2009) Journal of toxicology and environmental health. Part A 72, 577-84. PMID: 19296407

5. Morgan, CA. et al. (2015) Chemico-biological interactions 234, 29-37. PMID: 25450233

6. Koch, MF. et al. (2015) Angewandte Chemie (International ed. in English) 54, 13550-4. PMID: 26373694

Note

For research use only.

图片

参考文献

产品说明书

Anti-ALDH1A1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-ALDH1A1 Polyclonal Antibody (HF669014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-ALDH1A1 Polyclonal Antibody (HF669014)

概述

图片

参考文献

产品说明书

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