Anti-IL-1 beta/IL-1F2 Polyclonal Antibody (HF943014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HF943014

品牌

abinScience

描述

Anti-IL1B/IL1F2 Polyclonal Antibody (HF943014) is a rabbit polyclonal antibody detecting IL1F2 in ELISA, IHC, WB. Suitable for Human, Cercocebus atys, Macaca fascicularis, Macaca mulatta, and Macaca nemestrina.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human IL1B/IL1F2 (Ala117-Ser269).

靶标

Interleukin-1 beta, IL1B, Catabolin, IL1F2, IL-1 beta, IL-1β

纯化方式

Purified by antigen affinity column.

Accession号

P01584

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Interleukin-1 beta (IL1B/IL1F2) is a ~30 kDa protein. Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. IL1B is the therapeutic target of canakinumab (Ilaris).

1. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850

2. Nakahara, H. et al. (2003) Arthritis and rheumatism 48, 1521-9. PMID: 12794819

3. LaRock, CN. et al. (2016) Science immunology 1. PMID: 28331908

4. Van Damme, J. et al. (1985) Nature 314, 266-8. PMID: 3920526

5. Tian, XX. et al. (2021) International endodontic journal 54, 916-925. PMID: 33377178

6. Xia, S. et al. (2021) Nature 593, 607-611. PMID: 33883744

Note

For research use only.

图片

参考文献

产品说明书

Anti-IL-1 beta/IL-1F2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-IL-1 beta/IL-1F2 Polyclonal Antibody (HF943014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-IL-1 beta/IL-1F2 Polyclonal Antibody (HF943014)

概述

图片

参考文献

产品说明书

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