| 背景 | Stromelysin-1 (MMP3) is a ~53 kDa protein. Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Also acts intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. 1. Arza, B. et al. (2000) European journal of biochemistry 267, 6378-84. PMID: 110295802. Ogata, Y. et al. (1992) The Journal of biological chemistry 267, 3581-4. PMID: 13712713. Nagase, H. et al. (1990) Biochemistry 29, 5783-9. PMID: 23835574. Shin, EJ. et al. (2012) Neurochemistry international 60, 249-56. PMID: 222658215. Choi, DH. et al. (2011) The Journal of biological chemistry 286, 14168-77. PMID: 213303696. Feng, T. et al. (2022) Antiviral research 206, 105388. PMID: 35940311 |
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