Anti-FURIN Polyclonal Antibody (HY484014)

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100ug

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概述
图片
参考文献
产品说明书

概述

货号

HY484014

品牌

abinScience

描述

Anti-FURIN Polyclonal Antibody (HY484014) is a rabbit polyclonal antibody detecting FURIN in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human FURIN (Thr105-Ile221).

靶标

FUR, PCSK3, PACE, FURIN, Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, Furin

纯化方式

Purified by antigen affinity column.

Accession号

P09958

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Furin is a ~86 kDa protein. Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells.

1. Anderson, ED. et al. (2002) The Journal of biological chemistry 277, 12879-90. PMID: 11799113

2. Leduc, R. et al. (1992) The Journal of biological chemistry 267, 14304-8. PMID: 1629222

3. Barr, PJ. et al. (1991) DNA and cell biology 10, 319-28. PMID: 1713771

4. Wise, RJ. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 9378-82. PMID: 2251280

5. Dahms, SO. et al. (2014) ACS chemical biology 9, 1113-8. PMID: 24666235

6. Hardes, K. et al. (2015) ChemMedChem 10, 1218-31. PMID: 25974265

7. Takahashi, S. et al. (1995) The Journal of biological chemistry 270, 26565-9. PMID: 7592877

8. Takahashi, S. et al. (1993) Biochemical and biophysical research communications 195, 1019-26. PMID: 7690548

9. Anderson, ED. et al. (1997) The EMBO journal 16, 1508-18. PMID: 9130696

10. Dubois, CM. et al. (1995) The Journal of biological chemistry 270, 10618-24. PMID: 7737999

Note

For research use only.

图片

参考文献

产品说明书

Anti-FURIN Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-FURIN Polyclonal Antibody (HY484014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-FURIN Polyclonal Antibody (HY484014)

概述

图片

参考文献

产品说明书

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