Serine/threonine-protein kinase pim-1 (PIM1) is a ~35 kDa protein. Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. 1. Stout, BA. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 6409-17. PMID: 155283812. Saris, CJ. et al. (1991) The EMBO journal 10, 655-64. PMID: 18258103. Padi, SKR. et al. (2019) Proceedings of the National Academy of Sciences of the United States of America 116, 20505-20510. PMID: 315483944. Morishita, D. et al. (2008) Cancer research 68, 5076-85. PMID: 185939066. Bachmann, M. et al. (2006) The international journal of biochemistry & cell biology 38, 430-43. PMID: 163567547. Wang, Z. et al. (2002) Biochimica et biophysica acta 1593, 45-55. PMID: 124317839. Fisch, D. et al. (2023) Science (New York, N.Y.) 382, eadg2253. PMID: 37797010 | 
