| 靶标 | CYP11B1, Cytochrome P-450c11, Steroid 11-beta-hydroxylase, CYP11B1, Cytochrome P450C11, CYPXIB1, Cytochrome P450 11B1, mitochondrial, S11BH |
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| 背景 | Cytochrome P450 11B1, mitochondrial (CYP11B1) is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19. Catalyzes the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. 1. Bureik, M. et al. (2002) Endocrine research 28, 351-5. PMID: 125306362. Pascoe, L. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 8327-31. PMID: 15188663. Curnow, KM. et al. (1991) Molecular endocrinology (Baltimore, Md.) 5, 1513-22. PMID: 17751354. Zöllner, A. et al. (2008) The FEBS journal 275, 799-810. PMID: 182151635. Strushkevich, N. et al. (2013) Molecular endocrinology (Baltimore, Md.) 27, 315-24. PMID: 23322723 |
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