Anti-JAK1 Polyclonal Antibody (HB829014)

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50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HB829014

品牌

abinScience

描述

Anti-JAK1 Polyclonal Antibody (HB829014) is a rabbit polyclonal antibody detecting JAK1 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human JAK1 (Pro32-Phe286).

靶标

JAK1B, JAK1, Janus kinase 1, Tyrosine-protein kinase JAK1, JAK1A, JAK-1

纯化方式

Purified by antigen affinity column.

Accession号

P23458

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Tyrosine-protein kinase JAK1 is a ~133 kDa protein. Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.

1. Staerk, J. et al. (2005) The Journal of biological chemistry 280, 41893-9. PMID: 16239216

2. Del Bel, KL. et al. (2017) The Journal of allergy and clinical immunology 139, 2016-2020.e5. PMID: 28111307

3. Gruber, CN. et al. (2020) Immunity 53, 672-684.e11. PMID: 32750333

4. Sakatsume, M. et al. (1995) The Journal of biological chemistry 270, 17528-34. PMID: 7615558

5. Müller, M. et al. (1993) Nature 366, 129-35. PMID: 8232552

6. Simoncic, PD. et al. (2002) Current biology : CB 12, 446-53. PMID: 11909529

7. Usacheva, A. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 1302-8. PMID: 12133952

8. Novick, D. et al. (1995) Journal of leukocyte biology 57, 712-8. PMID: 7759950

Note

For research use only.

图片

Western blot

Western blot analysis was performed using anti-JAK1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: PC-12 cell lysate

参考文献

产品说明书

Anti-JAK1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-JAK1 Polyclonal Antibody (HB829014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-JAK1 Polyclonal Antibody (HB829014)

概述

图片

参考文献

产品说明书

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