Anti-MSN Polyclonal Antibody (HB033014)

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概述
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产品说明书

概述

货号

HB033014

品牌

abinScience

描述

Anti-MSN Polyclonal Antibody (HB033014) is a rabbit polyclonal antibody detecting MSN in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pig.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human MSN (Ile354-Met577).

靶标

Membrane-organizing extension spike protein, MSN, Moesin

纯化方式

Purified by antigen affinity column.

Accession号

P26038

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Moesin (MSN) is a ~67 kDa protein. Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs.

1. Huang, L. et al. (1999) The Journal of biological chemistry 274, 12803-10. PMID: 10212266

2. Urzainqui, A. et al. (2002) Immunity 17, 401-12. PMID: 12387735

3. Iontcheva, I. et al. (2004) Infection and immunity 72, 2312-20. PMID: 15039356

4. Serrador, JM. et al. (1997) The Journal of cell biology 138, 1409-23. PMID: 9298994

5. Serrador, JM. et al. (1998) Blood 91, 4632-44. PMID: 9616160

6. Lagresle-Peyrou, C. et al. (2016) The Journal of allergy and clinical immunology 138, 1681-1689.e8. PMID: 27405666

Note

For research use only.

图片

参考文献

产品说明书

Anti-MSN Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-MSN Polyclonal Antibody (HB033014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-MSN Polyclonal Antibody (HB033014)

概述

图片

参考文献

产品说明书

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