Anti-CHRNA3 Polyclonal Antibody (HB019014)

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概述
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参考文献
产品说明书

概述

货号

HB019014

品牌

abinScience

描述

Anti-CHRNA3 Polyclonal Antibody (HB019014) is a rabbit polyclonal antibody detecting CHRNA3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Chicken.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human CHRNA3 (Ser32-Leu240).

靶标

NACHRA3, Neuronal acetylcholine receptor subunit alpha-3, CHRNA3

纯化方式

Purified by antigen affinity column.

Accession号

P32297

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3) is a ~57 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA3 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, with CHRNA5, and CHRNB3 as accesory subunits. CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor.

1. Gharpure, A. et al. (2019) Neuron 104, 501-511.e6. PMID: 31488329

2. Mann, N. et al. (2019) American journal of human genetics 105, 1286-1293. PMID: 31708116

3. Kuryatov, A. et al. (2011) Molecular pharmacology 79, 119-25. PMID: 20881005

4. Wang, F. et al. (1996) The Journal of biological chemistry 271, 17656-65. PMID: 8663494

Note

For research use only.

图片

参考文献

产品说明书

Anti-CHRNA3 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CHRNA3 Polyclonal Antibody (HB019014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CHRNA3 Polyclonal Antibody (HB019014)

概述

图片

参考文献

产品说明书

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