Anti-GPX4 Polyclonal Antibody (HW551014)

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50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HW551014

品牌

abinScience

描述

Anti-GPX4 Polyclonal Antibody (HW551014) is a rabbit polyclonal antibody detecting GPX4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Callithrix jacchus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human GPX4 (Gly73-Phe196).

靶标

PHGPx, Glutathione peroxidase 4, GPX4, GSHPx-4, GPx-4, Phospholipid hydroperoxide glutathione peroxidase

纯化方式

Purified by antigen affinity column.

Accession号

P36969

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Phospholipid hydroperoxide glutathione peroxidase GPX4 (PHGPx) is a ~22 kDa protein. Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis.

1. Zheng, P. et al. (2025) Nature chemical biology 21, 1420-1432. PMID: 40281343

2. Yang, WS. et al. (2014) Cell 156, 317-331. PMID: 24439385

3. Sutherland, M. et al. (2001) The Biochemical journal 353, 91-100. PMID: 11115402

4. Schwarz, M. et al. (2023) Redox biology 59, 102593. PMID: 36608588

5. Scheerer, P. et al. (2007) Biochemistry 46, 9041-9. PMID: 17630701

Note

For research use only.

图片

参考文献

产品说明书

Anti-GPX4 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-GPX4 Polyclonal Antibody (HW551014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-GPX4 Polyclonal Antibody (HW551014)

概述

图片

参考文献

产品说明书

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