| 靶标 | HNGS1, Double-strand break repair protein MRE11, MRE11A, Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog A, MRE11 homolog A, MRE11 homolog 1, MRE11, Meiotic recombination 11 homolog 1 |
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| 背景 | Double-strand break repair protein MRE11 is a ~80 kDa protein. Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection. 1. de Jager, M. et al. (2001) Molecular cell 8, 1129-35. PMID: 117415472. Carson, CT. et al. (2003) The EMBO journal 22, 6610-20. PMID: 146570323. Park, YB. et al. (2011) Structure (London, England : 1993) 19, 1591-602. PMID: 220785594. Limbo, O. et al. (2012) Nucleic acids research 40, 11435-49. PMID: 230801216. Kijas, AW. et al. (2015) Nucleic acids research 43, 8352-67. PMID: 262403758. Myler, LR. et al. (2017) Molecular cell 67, 891-898.e4. PMID: 28867292 |
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