Anti-CPT1A Polyclonal Antibody (HW523014)

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概述
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参考文献
产品说明书

概述

货号

HW523014

品牌

abinScience

描述

Anti-CPT1A Polyclonal Antibody (HW523014) is a rabbit polyclonal antibody detecting CPT1A in ELISA, IHC, WB. Suitable for Human, Mouse, and Equus caballus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human CPT1A (Gln406-Thr745).

靶标

CPT1, CPTI-L, Carnitine O-palmitoyltransferase I, liver isoform, CPT1A, CPT I, Carnitine palmitoyltransferase 1A, CPT1-L, Carnitine O-palmitoyltransferase 1, liver isoform

纯化方式

Purified by antigen affinity column.

Accession号

P50416

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) is a ~88 kDa protein. Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity. Plays an important role in hepatic triglyceride metabolism. Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression. Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation.

1. Prip-Buus, C. et al. (2001) Molecular genetics and metabolism 73, 46-54. PMID: 11350182

2. Gobin, S. et al. (2003) The Journal of biological chemistry 278, 50428-34. PMID: 14517221

3. Wolfgang, MJ. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 7282-7. PMID: 16651524

4. IJlst, L. et al. (1998) The Journal of clinical investigation 102, 527-31. PMID: 9691089

5. Kurmi, K. et al. (2018) Cell reports 22, 1365-1373. PMID: 29425493

6. Zhang, G. et al. (2023) Molecular cell 83, 4370-4385.e9. PMID: 38016475

Note

For research use only.

图片

参考文献

产品说明书

Anti-CPT1A Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CPT1A Polyclonal Antibody (HW523014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CPT1A Polyclonal Antibody (HW523014)

概述

图片

参考文献

产品说明书

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