Anti-CD239/BCAM Polyclonal Antibody (HW406014)

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100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HW406014

品牌

abinScience

描述

Anti-CD239/BCAM Polyclonal Antibody (HW406014) is a rabbit polyclonal antibody detecting CD239 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human CD239/BCAM (Glu32-His257).

靶标

Basal cell adhesion molecule, LU, MSK19, Auberger B antigen, CD239, Lutheran blood group glycoprotein, Lutheran antigen, F8/G253 antigen, B-CAM cell surface glycoprotein, BCAM

纯化方式

Purified by antigen affinity column.

Accession号

P50895

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Basal cell adhesion molecule (CD239/BCAM) is a ~67 kDa protein. Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR.

1. Udani, M. et al. (1998) The Journal of clinical investigation 101, 2550-8. PMID: 9616226

2. Guadall, A. et al. (2019) The Journal of biological chemistry 294, 14911-14921. PMID: 31413112

3. El Nemer, W. et al. (2007) Blood 109, 3544-51. PMID: 17158232

4. Gauthier, E. et al. (2005) The Journal of biological chemistry 280, 30055-62. PMID: 15975931

5. De Grandis, M. et al. (2013) Blood 121, 658-65. PMID: 23160466

Note

For research use only.

图片

参考文献

产品说明书

Anti-CD239/BCAM Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CD239/BCAM Polyclonal Antibody (HW406014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CD239/BCAM Polyclonal Antibody (HW406014)

概述

图片

参考文献

产品说明书

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