Anti-BLK Polyclonal Antibody (HW362014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HW362014

品牌

abinScience

描述

Anti-BLK Polyclonal Antibody (HW362014) is a rabbit polyclonal antibody detecting BLK in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human BLK (Leu241-Tyr494).

靶标

Tyrosine-protein kinase Blk, BLK, p55-Blk, B lymphocyte kinase

纯化方式

Purified by antigen affinity column.

Accession号

P51451

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Tyrosine-protein kinase Blk is a ~57 kDa protein. Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'.

1. Bewarder, N. et al. (1996) Molecular and cellular biology 16, 4735-43. PMID: 8756631

2. Borowiec, M. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 14460-5. PMID: 19667185

3. Liu, H. et al. (2018) Nature 563, 131-136. PMID: 30356214

Note

For research use only.

图片

参考文献

产品说明书

Anti-BLK Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-BLK Polyclonal Antibody (HW362014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-BLK Polyclonal Antibody (HW362014)

概述

图片

参考文献

产品说明书

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