Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
产品使用信息
应用方法
稀释比例
ELISA
1:5000-1:20000
IHC
1:50-1:500
WB
1:500-1:2000
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Host cell factor 1 (HCFC1) is a ~208 kDa protein. Transcriptional coregulator. Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators. Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2.
1. Vinckevicius, A. et al. (2015) Molecular and cellular biology 35, 4135-46. PMID: 26416877
2. Mahajan, SS. et al. (2000) Molecular and cellular biology 20, 919-28. PMID: 10629049
3. Scarr, RB. et al. (2000) Molecular and cellular biology 20, 3568-75. PMID: 10779346
4. Khurana, B. et al. (2004) The Journal of biological chemistry 279, 33673-83. PMID: 15190068
5. Vogel, JL. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 6817-22. PMID: 16624878
6. Zhou, P. et al. (2013) The Journal of biological chemistry 288, 17532-43. PMID: 23629655
7. Vogel, JL. et al. (2000) The EMBO journal 19, 683-90. PMID: 10675337
8. Piluso, D. et al. (2002) The Journal of biological chemistry 277, 46799-808. PMID: 12244100
9. Luciano, RL. et al. (2003) The Journal of biological chemistry 278, 51116-24. PMID: 14532282
10. Wysocka, J. et al. (2003) Genes & development 17, 896-911. PMID: 12670868
