Anti-KPNA2 Polyclonal Antibody (HW788014)

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概述
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产品说明书

概述

货号

HW788014

品牌

abinScience

描述

Anti-KPNA2 Polyclonal Antibody (HW788014) is a rabbit polyclonal antibody detecting KPNA2 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human KPNA2 (Ala157-Gln412).

靶标

SRP1-alpha, Karyopherin subunit alpha-2, RAG cohort protein 1, RCH1, Importin subunit alpha-1, KPNA2, SRP1

纯化方式

Purified by antigen affinity column.

Accession号

P52292

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Importin subunit alpha-1 (KPNA2) is a ~57 kDa protein. Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

1. Zheng, W. et al. (2018) Traffic (Copenhagen, Denmark) 19, 19-28. PMID: 28991411

2. Cai, Z. et al. (2020) The Journal of experimental medicine 217. PMID: 32130408

3. Moroianu, J. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 6532-6. PMID: 7604027

4. Weis, K. et al. (1995) Science (New York, N.Y.) 268, 1049-53. PMID: 7754385

5. Yang, TJ. et al. (2022) The Journal of cell biology 221. PMID: 35446349

Note

For research use only.

图片

参考文献

产品说明书

Anti-KPNA2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-KPNA2 Polyclonal Antibody (HW788014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-KPNA2 Polyclonal Antibody (HW788014)

概述

图片

参考文献

产品说明书

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