Anti-STAT2 Polyclonal Antibody (HW807014)

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概述
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参考文献
产品说明书

概述

货号

HW807014

品牌

abinScience

描述

Anti-STAT2 Polyclonal Antibody (HW807014) is a rabbit polyclonal antibody detecting STAT2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human STAT2 (Glu616-Ser849).

靶标

p113, STAT2, Signal transducer and activator of transcription 2

纯化方式

Purified by antigen affinity column.

Accession号

P52630

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Signal transducer and activator of transcription 2 (STAT2) is a ~97 kDa protein. Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs.

1. Hambleton, S. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 3053-8. PMID: 23391734

2. Bluyssen, HA. et al. (1997) The Journal of biological chemistry 272, 4600-5. PMID: 9020188

3. Arimoto, KI. et al. (2017) Nature structural & molecular biology 24, 279-289. PMID: 28165510

4. Shahni, R. et al. (2015) Brain : a journal of neurology 138, 2834-46. PMID: 26122121

Note

For research use only.

图片

参考文献

产品说明书

Anti-STAT2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-STAT2 Polyclonal Antibody (HW807014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-STAT2 Polyclonal Antibody (HW807014)

概述

图片

参考文献

产品说明书

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