

| 货号 | HW822014 | ||||||||
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| 品牌 | abinScience | ||||||||
| 描述 |
Anti-CAPZA1 Polyclonal Antibody (HW822014) is a rabbit polyclonal antibody detecting CAPZA1 in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Cat, and Aotus nancymaae.
Highlights
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| 种属反应性 | Human, Mouse, Rat | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 同种型 | IgG | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 免疫原 | E. coli - derived recombinant Human CAPZA1 (Met1-Ala286). | ||||||||
| 靶标 | CapZ alpha-1, CAPZA1, F-actin-capping protein subunit alpha-1 | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | P52907 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | F-actin-capping protein subunit alpha-1 (CAPZA1) is a ~32 kDa protein. F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. 1. Elbediwy, A. et al. (2012) The Journal of cell biology 198, 677-93. PMID: 22891260 | ||||||||
| Note | For research use only. |

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