| 靶标 | CASP7, ICE-LAP3, CASP-7, MCH3, Caspase-7, CMH-1, ICE-like apoptotic protease 3, Apoptotic protease Mch-3 |
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| 背景 | Caspase-7 (CASP7) is a ~34 kDa protein. Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins. Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences. Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7. Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of proteins, such as CLSPN, PARP1, PTGES3 and YY1. Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins. 4. Hardy, JA. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 12461-6. PMID: 153142335. Denault, JB. et al. (2006) Molecular cell 23, 523-33. PMID: 169166406. Young, JE. et al. (2007) The Journal of biological chemistry 282, 30150-60. PMID: 176461707. Walsh, JG. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 12815-9. PMID: 187236808. Hardy, JA. et al. (2009) The Journal of biological chemistry 284, 26063-9. PMID: 195816399. Fernandes-Alnemri, T. et al. (1995) Cancer research 55, 6045-52. PMID: 852139110. Lippke, JA. et al. (1996) The Journal of biological chemistry 271, 1825-8. PMID: 8567622 |
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