Anti-ADK Polyclonal Antibody (HX989014)

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概述
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参考文献
产品说明书

概述

货号

HX989014

品牌

abinScience

描述

Anti-ADK Polyclonal Antibody (HX989014) is a rabbit polyclonal antibody detecting ADK in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Cricetulus griseus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human ADK (Ile94-Ala339).

靶标

Adenosine 5'-phosphotransferase, ADK, AK, Adenosine kinase

纯化方式

Purified by antigen affinity column.

Accession号

P55263

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Adenosine kinase (ADK) is a ~40 kDa protein. Adenosine kinase that mediates the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner: catalyzes phosphorylation of both unmodified and modified adenosines. Plays a key role in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification. Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction. Catalyzes the phosphorylation of the free cytosolic methylated adenosine nucleotides N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) into adenosine monophosphate (AMP) intermediates that are further detoxified by MAPDA/ADAL.

1. Bjursell, MK. et al. (2011) American journal of human genetics 89, 507-15. PMID: 21963049

2. Ogawa, A. et al. (2025) Cell 188, 6151-6169.e24. PMID: 40840445

3. Palella, TD. et al. (1980) The Journal of biological chemistry 255, 5264-9. PMID: 6246102

4. Spychala, J. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 1232-7. PMID: 8577746

5. McNally, T. et al. (1997) Biochemical and biophysical research communications 231, 645-50. PMID: 9070863

Note

For research use only.

图片

参考文献

产品说明书

Anti-ADK Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-ADK Polyclonal Antibody (HX989014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-ADK Polyclonal Antibody (HX989014)

概述

图片

参考文献

产品说明书

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