Anti-SUMO2 Polyclonal Antibody (HX919014)

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概述
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参考文献
产品说明书

概述

货号

HX919014

品牌

abinScience

描述

Anti-SUMO2 Polyclonal Antibody (HX919014) is a rabbit polyclonal antibody detecting SUMO2 in ELISA, IHC, WB. Suitable for Bovine, Cricetulus griseus, Danio rerio, Chicken, and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human SUMO2 (Met1-Tyr95).

靶标

Ubiquitin-like protein SMT3B, SMT3B, SUMO-3, Smt3B, Sentrin-2, SMT3 homolog 2, SMT3H2, SUMO2, HSMT3, Small ubiquitin-related modifier 2, SUMO-2

纯化方式

Purified by antigen affinity column.

Accession号

P61956

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Small ubiquitin-related modifier 2 (SUMO2) is a ~10 kDa protein. Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX.

1. Cappadocia, L. et al. (2015) Nature structural & molecular biology 22, 968-75. PMID: 26524494

2. Tatham, MH. et al. (2008) Nature cell biology 10, 538-46. PMID: 18408734

3. Meulmeester, E. et al. (2008) Molecular cell 30, 610-9. PMID: 18538659

4. Cong, L. et al. (2011) The Journal of biological chemistry 286, 43793-43808. PMID: 21965678

5. Kamitani, T. et al. (1998) The Journal of biological chemistry 273, 11349-53. PMID: 9556629

6. Richard, P. et al. (2013) Genes & development 27, 2227-32. PMID: 24105744

Note

For research use only.

图片

参考文献

产品说明书

Anti-SUMO2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-SUMO2 Polyclonal Antibody (HX919014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-SUMO2 Polyclonal Antibody (HX919014)

概述

图片

参考文献

产品说明书

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