Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B) (HW601107)

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货号	HW601107
品牌	abinScience
种属反应性	Human
应用	FCM
同种型	IgG1, kappa
克隆号	VB22B
靶标	TPO-R, TPOR, Thrombopoietin receptor, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P40238
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Thrombopoietin receptor (CD110/MPL) is a ~71 kDa protein. Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production. 1. Royer, Y. et al. (2005) The Journal of biological chemistry 280, 27251-61. PMID: 15899890 2. Tsutsumi, N. et al. (2023) Cell 186, 4189-4203.e22. PMID: 37633268
Note	For research use only.

Bioactivity

Detects CD110/MPL in indirect ELISAs.
Western blot

Western blot analysis was performed using anti-CD110/MPL monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD110/MPL (Catalog No: HW601011)
Lane 2: negative control

产品说明书

Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B).pdf

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Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B) (HW601107)

概述

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参考文献

产品说明书

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重组蛋白

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实验相关试剂

Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B) (HW601107)

概述

图片

参考文献

产品说明书

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