Anti-Human CD119/IFNGR1 Recombinant Antibody (SAA0044) (HB990107)

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100ug

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货号	HB990107
品牌	abinScience
种属反应性	Human
应用	FCM
同种型	IgG1, kappa
克隆号	SAA0044
靶标	IFN-gamma-R1, Interferon gamma receptor 1, CDw119, Interferon gamma receptor alpha-chain, IFN-gamma receptor 1, IFNGR1, IFN-gamma-R-alpha, CD119
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P15260
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Interferon gamma receptor 1 (CD119/IFNGR1) is a ~54 kDa protein. Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription. 1. van de Wetering, D. et al. (2010) Molecular immunology 47, 1023-30. PMID: 20015550 2. Thiel, DJ. et al. (2000) Structure (London, England : 1993) 8, 927-36. PMID: 10986460 3. Aguet, M. et al. (1988) Cell 55, 273-80. PMID: 2971451 4. Sakatsume, M. et al. (1995) The Journal of biological chemistry 270, 17528-34. PMID: 7615558 5. Walter, MR. et al. (1995) Nature 376, 230-5. PMID: 7617032 6. Kotenko, SV. et al. (1995) The Journal of biological chemistry 270, 20915-21. PMID: 7673114 7. Londino, JD. et al. (2017) The Biochemical journal 474, 3543-3557. PMID: 28883123
Note	For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human CD119/IFNGR1 Antibody (SAA0044)

产品说明书

Anti-Human CD119/IFNGR1 Recombinant Antibody (SAA0044).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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C₁ × V₁ = C₂ × V₂

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C₁ (起始浓度)

V₁ (起始体积)

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Anti-Human CD119/IFNGR1 Recombinant Antibody (SAA0044) (HB990107)

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Anti-Human CD119/IFNGR1 Recombinant Antibody (SAA0044) (HB990107)

概述

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参考文献

产品说明书

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