Anti-Human HGFR/c-MET Recombinant Antibody (224G11) (HY196207)

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货号	HY196207
品牌	abinScience
种属反应性	Human
应用	FCM
同种型	IgG1, kappa
克隆号	224G11
经测试应用	FCM
靶标	Tyrosine-protein kinase Met, Hepatocyte growth factor receptor, Proto-oncogene c-Met, Scatter factor receptor, HGF receptor, SF receptor, HGF/SF receptor, MET
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P08581
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Hepatocyte growth factor receptor (MET/HGFR) is a ~155 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. MET is the therapeutic target of amivantamab (Rybrevant).
Note	For research use only.

Flow Cytometry

Flow-cytometry using anti-human c-Met antibody.HeLa cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human c-Met antibody monoclonal antibody (Catalog # HY196207 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-human antibody (Catalog # HF690414) and cells analysed on a NovoCyte Flow Cytometer.
Flow Cytometry

Flow-cytometry using anti-human c-Met antibody.HepG2 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human c-Met antibody monoclonal antibody (Catalog # HY196207 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-human antibody (Catalog # HF690414) and cells analysed on a NovoCyte Flow Cytometer.
Flow Cytometry

Flow-cytometry using anti-human c-Met antibody.HT-29 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human c-Met antibody monoclonal antibody (Catalog # HY196207 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-human antibody (Catalog # HF690414) and cells analysed on a NovoCyte Flow Cytometer.

产品说明书

Anti-Human HGFR/c-MET Recombinant Antibody (224G11).pdf

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Anti-Human HGFR/c-MET Recombinant Antibody (224G11) (HY196207)

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参考文献

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实验相关试剂

Anti-Human HGFR/c-MET Recombinant Antibody (224G11) (HY196207)

概述

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参考文献

产品说明书

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