Anti-Human CD21/CR2 Recombinant Antibody (HB5) (HB939107)

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货号	HB939107
品牌	abinScience
种属反应性	Human
应用	FCM
同种型	IgG2a, kappa
克隆号	HB5
经测试应用	FCM
靶标	Cr2, Complement C3d receptor, C3DR, Epstein-Barr virus receptor, Complement receptor type 2, CR2, EBV receptor, CD21
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P20023
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Complement receptor type 2 (CD21/CR2) is a ~112 kDa protein. Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner. 1. Delcayre, AX. et al. (1991) The EMBO journal 10, 919-26. PMID: 1849076 2. van den Elsen, JM. et al. (2011) Science (New York, N.Y.) 332, 608-11. PMID: 21527715 3. Barel, M. et al. (1995) Molecular immunology 32, 389-97. PMID: 7753047 4. Bradbury, LE. et al. (1992) Journal of immunology (Baltimore, Md. : 1950) 149, 2841-50. PMID: 1383329 5. Franco, A. et al. (2018) International immunology 30, 569-578. PMID: 30107486 6. Barel, M. et al. (2003) European journal of immunology 33, 2557-66. PMID: 12938232 7. Aubry, JP. et al. (1992) Nature 358, 505-7. PMID: 1386409
Note	For research use only.

Flow Cytometry

Flow-cytometry using anti-human CD21 antibody. Human Jurkat cell line were stained with an irrelevant antibody (Green Histogram) or an anti-human CD21 antibody monoclonal antibody (Catalog # HB939107 , Red Histogram) at a concentration of 20 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a CoraLite488 conjugated goat anti-mouse antibody (Catalog # MF690314) and cells analysed on a NovoCyte Flow Cytometer.

产品说明书

Anti-Human CD21/CR2 Recombinant Antibody (HB5).pdf

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Anti-Human CD21/CR2 Recombinant Antibody (HB5) (HB939107)

概述

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参考文献

产品说明书

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重组蛋白

抗体

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实验相关试剂

Anti-Human CD21/CR2 Recombinant Antibody (HB5) (HB939107)

概述

图片

参考文献

产品说明书

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