Anti-Human CD367/CLEC4A Recombinant Antibody (9E8#) (HV145107)

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货号	HV145107
品牌	abinScience
种属反应性	Human
应用	FCM
同种型	IgG1, kappa
克隆号	9E8#
靶标	C-type lectin DDB27, CLECSF6, CLEC4A, LLIR, CD367, Lectin-like immunoreceptor, DCIR, C-type lectin domain family 4 member A, Dendritic cell immunoreceptor, C-type lectin superfamily member 6
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q9UMR7
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	C-type lectin domain family 4 member A (CD367/CLEC4A) is a ~27 kDa protein. C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. 1. Nagae, M. et al. (2016) FEBS letters 590, 1280-8. PMID: 27015765 2. Bates, EE. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1973-83. PMID: 10438934 3. Meyer-Wentrup, F. et al. (2008) Blood 111, 4245-53. PMID: 18258799 4. Klechevsky, E. et al. (2010) Blood 116, 1685-97. PMID: 20530286
Note	For research use only.

Bioactivity

Detects CD367/CLEC4A in indirect ELISAs.
Flow Cytometry

Flow-cytometry using anti-human CD367 antibody.CD367 Transfected CHO cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD367 antibody monoclonal antibody (Catalog # HV145107 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.

产品说明书

Anti-Human CD367/CLEC4A Recombinant Antibody (9E8#).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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C₁ × V₁ = C₂ × V₂

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C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

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Anti-Human CD367/CLEC4A Recombinant Antibody (9E8#) (HV145107)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CD367/CLEC4A Recombinant Antibody (9E8#) (HV145107)

概述

图片

参考文献

产品说明书

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