Anti-Mouse CD156c/ADAM10 Recombinant Antibody (8C7) (MT182107)

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货号	MT182107
品牌	abinScience
种属反应性	Human, Mouse, Bovine
应用	FCM, IF, IHC, IP
同种型	IgG1, kappa
克隆号	8C7
靶标	ADAM 10, Mammalian disintegrin-metalloprotease, CD156c, MADM, ADAM10, Kuzbanian protein homolog, KUZ, CDw156, Disintegrin and metalloproteinase domain-containing protein 10
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	O35598
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Disintegrin and metalloproteinase domain-containing protein 10 (CD156c/ADAM10) is a ~83 kDa protein. Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis. Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity. Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) at '687-Lys-\|-Leu-688'. 1. Li, N. et al. (2007) The EMBO journal 26, 494-504. PMID: 17245433 2. Wang, X. et al. (2018) Journal of molecular cell biology 10, 411-422. PMID: 29325091 3. Brummer, T. et al. (2018) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32, 3560-3573. PMID: 29430990 4. Defourny, J. et al. (2019) iScience 11, 246-257. PMID: 30639848 5. Noy, PJ. et al. (2016) The Journal of biological chemistry 291, 3145-57. PMID: 26668317 6. Shah, J. et al. (2018) Cell reports 25, 2132-2147.e7. PMID: 30463011 7. Pan, D. et al. (1997) Cell 90, 271-80. PMID: 9244301 8. Hammad, H. et al. (2017) Nature immunology 18, 313-320. PMID: 28068307
Note	For research use only.

Bioactivity

SEC-HPLC detection for Anti-Mouse CD156c/ADAM10 Antibody (8C7).
SDS-PAGE

SDS-PAGE for Anti-Mouse CD156c/ADAM10 Antibody (8C7)

产品说明书

Anti-Mouse CD156c/ADAM10 Recombinant Antibody (8C7).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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C₁ × V₁ = C₂ × V₂

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C₁ (起始浓度)

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Anti-Mouse CD156c/ADAM10 Recombinant Antibody (8C7) (MT182107)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse CD156c/ADAM10 Recombinant Antibody (8C7) (MT182107)

概述

图片

参考文献

产品说明书

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