Anti-Mouse Notch-1 Recombinant Antibody (SAA0270) (MW570107)

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货号	MW570107
品牌	abinScience
种属反应性	Human, Mouse
应用	ELISA, FCM
同种型	IgG1, kappa
克隆号	SAA0270
靶标	hN1, TAN1, NEXT, NICD, Notch 1, Neurogenic locus notch homolog protein 1, Translocation-associated notch protein TAN-1, NOTCH1
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q01705
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Neurogenic locus notch homolog protein 1 (NOTCH1) is a ~270 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus.
文献	1. NOTCH1 notch receptor 1 [Homo sapiens (human)] Gene ID: 4851, updated on 28-Oct-2019. [MW570107] 2. toyanova T, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6457-E6466. [MW570107]
Note	For research use only.

SDS-PAGE

SDS-PAGE for Anti-Mouse NOTCH1 Antibody (SAA0270)

产品说明书

Anti-Mouse Notch-1 Recombinant Antibody (SAA0270).pdf

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Anti-Mouse Notch-1 Recombinant Antibody (SAA0270) (MW570107)

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Anti-Mouse Notch-1 Recombinant Antibody (SAA0270) (MW570107)

概述

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参考文献

产品说明书

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