Anti-Human p53 (R175H mutant) Recombinant Antibody (F2) (HY039107)

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货号	HY039107
品牌	abinScience
种属反应性	Human
应用	ELISA, FCM
同种型	IgG2a, kappa
克隆号	F2
靶标	Antigen NY-CO-13, Cellular tumor antigen p53, P53, Tumor suppressor p53, TP53, Phosphoprotein p53
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P04637
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景	Cellular tumor antigen p53 (TP53) is a ~43 kDa protein. Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. 1. Guo, A. et al. (2000) Nature cell biology 2, 730-6. PMID: 11025664 2. Bergamaschi, D. et al. (2003) Nature genetics 33, 162-7. PMID: 12524540 3. Louria-Hayon, I. et al. (2003) The Journal of biological chemistry 278, 33134-41. PMID: 12810724 4. An, W. et al. (2004) Cell 117, 735-48. PMID: 15186775 5. Ghosh, A. et al. (2004) Molecular and cellular biology 24, 7987-97. PMID: 15340061 6. Zhao, Y. et al. (2007) The Journal of biological chemistry 282, 11969-81. PMID: 17317671 7. Taira, N. et al. (2007) Molecular cell 25, 725-38. PMID: 17349958 8. Allton, K. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 11612-6. PMID: 19556538 9. Huarte, M. et al. (2010) Cell 142, 409-19. PMID: 20673990 10. Wu, L. et al. (2011) The Journal of biological chemistry 286, 2236-44. PMID: 20959462
Note	For research use only.

SDS-PAGE

SDS-PAGE for Anti-Human TP53/p53 (R175H mutant) Antibody (F2)

产品说明书

Anti-Human p53 (R175H mutant) Recombinant Antibody (F2).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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Anti-Human p53 (R175H mutant) Recombinant Antibody (F2) (HY039107)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human p53 (R175H mutant) Recombinant Antibody (F2) (HY039107)

概述

图片

参考文献

产品说明书

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