

| 货号 | HY307217 |
|---|---|
| 品牌 | abinScience |
| 种属反应性 | Human |
| 应用 | ELISA, FCM, WB |
| 宿主 | Mouse |
| 同种型 | IgG2a |
| 克隆号 | SAA0839 |
| 偶联物 | FITC |
| 克隆类型 | Monoclonal |
| 靶标 | Complement decay-accelerating factor, CR, DAF, CD55 |
| 内毒素水平 | Please contact with the lab for this information. |
| 相关产品 | Mouse IgG2a Recombinant Isotype Control Antibody (C1.18.4), FITC |
| Accession号 | P08174 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | Complement decay-accelerating factor (CD55) is a ~41 kDa protein. This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage. 1. Ward, T. et al. (1994) The EMBO journal 13, 5070-4. PMID: 7525274 2. Ozen, A. et al. (2017) The New England journal of medicine 377, 52-61. PMID: 28657829 |
| Note | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |

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