| 货号 | HY574217 |
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| 品牌 | abinScience |
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| 种属反应性 | Human |
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| 应用 | FCM |
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| 宿主 | Mouse |
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| 同种型 | IgG1 |
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| 克隆号 | scFv17 |
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| 偶联物 | FITC |
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| 克隆类型 | Monoclonal |
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| 靶标 | Cathepsin G-like 1, Granzyme-2, GZMB, grzmB, Fragmentin-2, Human lymphocyte protein, HLP, CTLA-1, CGL1, CTSGL1, CSPB, Lymphocyte protease, T-cell serine protease 1-3E, Granzyme B, CTLA1, GRB, Granzyme-B, C11, Cytotoxic T-lymphocyte proteinase 2, SECT |
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| 内毒素水平 | Please contact with the lab for this information. |
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| 相关产品 |
Mouse IgG1 Recombinant Isotype Control Antibody (HyHEL-10), FITC
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| Accession号 | P10144 |
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| 状态 | Liquid |
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| 保存溶液 |
0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
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| 稳定性和存储 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
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| 背景 | Granzyme B (GZMB) is a ~27 kDa protein. Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis. 1. Poe, M. et al. (1991) The Journal of biological chemistry 266, 98-103. PMID: 19859272. Hameed, A. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 141, 3142-7. PMID: 32626823. Krähenbühl, O. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 141, 3471-7. PMID: 32634274. Froelich, CJ. et al. (1993) Journal of immunology (Baltimore, Md. : 1950) 151, 7161-71. PMID: 82587167. Yang, X. et al. (1998) The Journal of biological chemistry 273, 34278-83. PMID: 9852092 |
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| Note | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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