| 货号 | HY554117 |
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| 品牌 | abinScience |
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| 种属反应性 | Human |
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| 应用 | ELISA, FCM |
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| 宿主 | Mouse |
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| 同种型 | IgG1, kappa |
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| 克隆号 | SAA0376 |
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| 偶联物 | FITC |
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| 克隆类型 | Monoclonal |
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| 靶标 | GCP/IL-8 protein II, MDNCF, IL8/NAP1 form III, IL-8(1-77), Neutrophil-activating factor, GCP/IL-8 protein I, GCP/IL-8 protein VI, Interleukin-8, Chemokine (C-X-C motif) ligand 8, Neutrophil-activating protein 1, Monocyte-derived neutrophil chemotactic factor, (Ser-IL-8)72, MDNCF-b, LYNAP, GCP/IL-8 protein V, IL8/NAP1 form IV, MONAP, IL8/NAP1 form V, IL8/NAP1 form VI, NAP-1, Granulocyte chemotactic protein 1, GCP/IL-8 protein III, IL8/NAP1 form II, IL8, IL-8, CXCL8, IL8/NAP1 form I, (Ala-IL-8)77, Protein 3-10C, GCP/IL-8 protein IV, Emoctakin, GCP-1, C-X-C motif chemokine 8, NAF, T-cell chemotactic factor, MDNCF-c, Monocyte-derived neutrophil-activating peptide, Lymphocyte-derived neutrophil-activating factor |
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| 内毒素水平 | Please contact with the lab for this information. |
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| 相关产品 |
Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), FITC
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| Accession号 | P10145 |
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| 状态 | Liquid |
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| 保存溶液 |
0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
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| 稳定性和存储 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
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| 背景 | Interleukin-8 (IL8/CXCL8) is a ~11 kDa protein. Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways. 1. Zinkernagel, AS. et al. (2008) Cell host & microbe 4, 170-8. PMID: 186927762. Hammond, ME. et al. (1995) Journal of immunology (Baltimore, Md. : 1950) 155, 1428-33. PMID: 76362083. Van Damme, J. et al. (1990) European journal of immunology 20, 2113-8. PMID: 21451754. Jacobi, HH. et al. (1998) International archives of allergy and immunology 116, 53-9. PMID: 96235105. Holmes, WE. et al. (1991) Science (New York, N.Y.) 253, 1278-80. PMID: 18407016. Murphy, PM. et al. (1991) Science (New York, N.Y.) 253, 1280-3. PMID: 18917167. Takami, M. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 4559-66. PMID: 119710038. Damaj, BB. et al. (1996) The Journal of biological chemistry 271, 12783-9. PMID: 8662698 |
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| 文献 | 1. Edward John BERTACCINI, et al. Novel methods, compounds, and compositions for anesthesia. WO2016061538A1. 2018-12-05 [HY554117] |
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| Note | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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