Anti-Human BMP6 Recombinant Antibody (SAA0425), FITC (HB857117)

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货号	HB857117
品牌	abinScience
种属反应性	Human
应用	ELISA, FCM
宿主	Mouse
同种型	IgG2a, kappa
克隆号	SAA0425
偶联物	FITC
克隆类型	Monoclonal
靶标	VG-1-R, VG-1-related protein, Bone morphogenetic protein 6, VGR-1, BMP-6, VGR, BMP6
内毒素水平	Please contact with the lab for this information.
相关产品	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), FITC
Accession号	P22004
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Bone morphogenetic protein 6 (BMP6) is a ~57 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. 1. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025 2. Daher, R. et al. (2016) Gastroenterology 150, 672-683.e4. PMID: 26582087 3. Arezes, J. et al. (2018) Blood 132, 1473-1477. PMID: 30097509 4. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957 5. Saremba, S. et al. (2008) The FEBS journal 275, 172-83. PMID: 18070108 6. Pulkkinen, HH. et al. (2021) Angiogenesis 24, 129-144. PMID: 33021694
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

产品说明书

Anti-Human BMP6 Recombinant Antibody (SAA0425), FITC.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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C₁ × V₁ = C₂ × V₂

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C₁ (起始浓度)

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Anti-Human BMP6 Recombinant Antibody (SAA0425), FITC (HB857117)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human BMP6 Recombinant Antibody (SAA0425), FITC (HB857117)

概述

图片

参考文献

产品说明书

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