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Anti-Human BAG3 Antibody (SAA0529), PerCP (ARO-A10189)

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概述
货号ARO-A10189
品牌ProteoGenix
描述
Anti-Human BAG3 Antibody (SAA0529), PerCP [SAA0529] (ARO-A10189) is a human monoclonal antibody detecting Docking protein CAIR-1, BAG3, Bcl-2-associated athanogene 3, BAG family molecular chaperone regulator 3, Bcl-2-binding protein Bis, BAG-3, BIS in ELISA, FCM. Suitable for Human.
Highlights
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, FCM
宿主Human
同种型IgG2a, kappa
克隆号SAA0529
偶联物PerCP
克隆类型Monoclonal
靶标Docking protein CAIR-1, BAG3, Bcl-2-associated athanogene 3, BAG family molecular chaperone regulator 3, Bcl-2-binding protein Bis, BAG-3, BIS
内毒素水平Please contact with the lab for this information.
Accession号O95817
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Store at 4°C for 12 months. Protect from light. Do not freeze.
背景

BAG family molecular chaperone regulator 3 (BAG3) is a ~61 kDa protein. Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release. Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD).

1. Rauch, JN. et al. (2017) Journal of molecular biology 429, 128-141. PMID: 27884606
2. Meister-Broekema, M. et al. (2018) Nature communications 9, 5342. PMID: 30559338
3. Rauch, JN. et al. (2016) The Journal of biological chemistry 291, 19848-57. PMID: 27474739
4. Takayama, S. et al. (1999) The Journal of biological chemistry 274, 781-6. PMID: 9873016
5. Lee, JH. et al. (1999) Oncogene 18, 6183-90. PMID: 10597216
6. Jin, YH. et al. (2015) Biochemical and biophysical research communications 464, 561-7. PMID: 26159920
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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