Anti-Human CD193/CCR3 Recombinant Antibody (5E8-G9-B4), FITC (HW620117)

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货号	HW620117
品牌	abinScience
种属反应性	Human
应用	FCM
宿主	Mouse
同种型	IgG2b, kappa
克隆号	5E8-G9-B4
偶联物	FITC
克隆类型	Monoclonal
靶标	CCR-3, C-C chemokine receptor type 3, CKR3, CC-CKR-3, C-C CKR-3, CKR 3, CCR3, CMKBR3, CD193, C C CKR3, Eosinophil eotaxin receptor
内毒素水平	Please contact with the lab for this information.
相关产品	Mouse IgG2b, kappa Recombinant Isotype Control Antibody (MPC-11), FITC
Accession号	P51677
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	C-C chemokine receptor type 3 (CD193/CCR3) is a ~41 kDa protein. G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines. Selectively interacts with eosinophil-attracting chemokines such as eotaxin/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. Ligand binding triggers intracellular signaling that leads to chemotaxis of immune cells. Mechanistically, signals through GNA14 or GNA16 to induce stimulation of phospholipase Cbeta/PLCB2 and subsequently chemotaxis. Alternatively, transduces signal via GNAI1 resulting in elevated intracellular calcium levels and activation of the PI3K/AKT pathway. 1. Song, Y. et al. (2018) Biochemistry 57, 852-860. PMID: 28994588 2. Combadiere, C. et al. (1995) The Journal of biological chemistry 270, 16491-4. PMID: 7622448 3. Daugherty, BL. et al. (1996) The Journal of experimental medicine 183, 2349-54. PMID: 8642344 4. Ponath, PD. et al. (1996) The Journal of experimental medicine 183, 2437-48. PMID: 8676064 5. Tian, Y. et al. (2008) Cellular signalling 20, 1179-89. PMID: 18406577 6. Shao, Z. et al. (2022) Cell discovery 8, 44. PMID: 35570218 7. Park, JS. et al. (2018) International journal of biological macromolecules 120, 835-845. PMID: 30171954
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

产品说明书

Anti-Human CD193/CCR3 Recombinant Antibody (5E8-G9-B4), FITC.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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C₁ × V₁ = C₂ × V₂

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Anti-Human CD193/CCR3 Recombinant Antibody (5E8-G9-B4), FITC (HW620117)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

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实验相关试剂

Anti-Human CD193/CCR3 Recombinant Antibody (5E8-G9-B4), FITC (HW620117)

概述

图片

参考文献

产品说明书

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