

| 货号 | ARO-A10984 |
|---|---|
| 品牌 | ProteoGenix |
| 描述 |
Anti-Human CD304/NRP1 Antibody (SAA0097), FITC [SAA0097] (ARO-A10984) is a human monoclonal antibody detecting NRP1, Neuropilin-1, VEGF165R, NRP, CD304, Vascular endothelial cell growth factor 165 receptor in FCM. Suitable for Human.
Highlights
|
| 种属反应性 | Human |
| 应用 | FCM |
| 宿主 | Human |
| 同种型 | IgG1, kappa |
| 克隆号 | SAA0097 |
| 偶联物 | FITC |
| 克隆类型 | Monoclonal |
| 靶标 | NRP1, Neuropilin-1, VEGF165R, NRP, CD304, Vascular endothelial cell growth factor 165 receptor |
| 内毒素水平 | Please contact with the lab for this information. |
| Accession号 | O14786 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | Neuropilin-1 (CD304/NRP1) is a ~103 kDa protein. Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. 1. Gagnon, ML. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 2573-8. PMID: 10688880 2. He, Z. et al. (1997) Cell 90, 739-51. PMID: 9288753 3. Soker, S. et al. (1998) Cell 92, 735-45. PMID: 9529250 4. Teesalu, T. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 16157-62. PMID: 19805273 5. Issitt, T. et al. (2019) iScience 11, 205-223. PMID: 30623799 |
| Note | For research use only. |

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