Anti-Human TRBC1 Recombinant Antibody (Jovi-1), FITC (HP894117)

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货号	HP894117
品牌	abinScience
种属反应性	Human
应用	ELISA, FCM, IF
宿主	Mouse
同种型	IgG2a, kappa
克隆号	Jovi-1
偶联物	FITC
克隆类型	Monoclonal
靶标	TRBC1, T cell receptor beta constant 1
内毒素水平	Please contact with the lab for this information.
相关产品	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), FITC
Accession号	P01850
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	T cell receptor beta constant 1 (TRBC1) is a ~19 kDa protein. Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. 1. Lefranc, MP. (2014) Frontiers in immunology 5, 22. PMID: 24600447 2. Rossjohn, J. et al. (2015) Annual review of immunology 33, 169-200. PMID: 25493333 3. Brownlie, RJ. et al. (2013) Nature reviews. Immunology 13, 257-69. PMID: 23524462 4. Bäckström, BT. et al. (1997) The Journal of experimental medicine 186, 1933-8. PMID: 9382891 5. Nikolich-Zugich, J. et al. (2004) Nature reviews. Immunology 4, 123-32. PMID: 15040585
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Flow CytoMetry

Flow-cytometry using FITC anti-human TRBC1 antibody. Jurkat cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human TRBC1 monoclonal antibody (Catalog: HP894117, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

产品说明书

Anti-Human TRBC1 Recombinant Antibody (Jovi-1), FITC.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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Anti-Human TRBC1 Recombinant Antibody (Jovi-1), FITC (HP894117)

概述

图片

参考文献

产品说明书

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重组蛋白

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实验相关试剂

Anti-Human TRBC1 Recombinant Antibody (Jovi-1), FITC (HP894117)

概述

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参考文献

产品说明书

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