Anti-Human TCR β Recombinant Antibody (IARC307), FITC (HP468117)

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货号	HP468117
品牌	abinScience
种属反应性	Human
应用	FCM
宿主	Mouse
同种型	IgG1, kappa
克隆号	IARC307
偶联物	FITC
克隆类型	Monoclonal
靶标	T-cell receptor beta chain V region YT35, TCRBV8S1, TCRBV12S3, T cell receptor beta variable 12-3, TRBV12-3
内毒素水平	Please contact with the lab for this information.
相关产品	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), FITC
Accession号	P01733
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	T cell receptor beta variable 12-3 (TCRβ) is a ~12 kDa protein. V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. 1. Lefranc, MP. (2014) Frontiers in immunology 5, 22. PMID: 24600447 2. Rossjohn, J. et al. (2015) Annual review of immunology 33, 169-200. PMID: 25493333 3. Brownlie, RJ. et al. (2013) Nature reviews. Immunology 13, 257-69. PMID: 23524462 4. Nikolich-Zugich, J. et al. (2004) Nature reviews. Immunology 4, 123-32. PMID: 15040585
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

产品说明书

Anti-Human TCR β Recombinant Antibody (IARC307), FITC.pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

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C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

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Anti-Human TCR β Recombinant Antibody (IARC307), FITC (HP468117)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human TCR β Recombinant Antibody (IARC307), FITC (HP468117)

概述

图片

参考文献

产品说明书

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